Preventing Fatigue in Women With Breast Cancer Treated With Chemotherapy.
Abstract
This is the second annual report on a randomized, double-blind, placebo-controlled clinical trial of 130 consecutive breast cancer patients who are being studied over four successive chemotherapy treatments to assess if an antidepressant drug can attenuate or prevent the development of fatigue in women during chemotherapy treatment. We are also examining the potential role of depression, sleep disturbance and the cytokine TNF-alpa in the development of fatigue during chemotherapy treatment Patients are randomized to take the antidepressant paroxetine (Paxil)(tradename) or placebo once a day during the trial. They complete standardized psychometric measures of fatigue and depression on the 7th day following each of the four chemotherapy cycles. Patient motion is assessed as a concomitant measure of fatigue by ambulatory electronic monitoring during the second and fourth assessments. Blood levels of TNF-alpha are also measured at these two treatments.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1998
- Accession Number
- ADA358060
Entities
People
- Gary R. Morrow
Organizations
- University of Rochester