Effects of Pyridostigmine in Flinders Line Rats Differing in Cholinergic Sensitivity.

Abstract

Within 30 min, acute pyridostigmine treatment induced elevations of seruni growth hormone levels to a greater extent in Flinders Sensitive Line (FSL) and Sprague-Dawley (SD) rats compared to Flinders Resistant (FRL) rats, without affecting temperature or activity. This finding confirms the cholinergic supersensitivity of the FSL rats but also indicates that the FRL rats are very resistant as well. All groups exhibited growth hormone elevations at 30 min following 12 mg/kg, so this dose of pyridostigmine was given chronically for 14 days before challenging the rats with chlorpyrifos (CPF, 60 mg/kg orally) or diisopropylfluorophosphate (DFP, 1 mg/kg sc).

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1998
Accession Number
ADA358065

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  • David H. Overstreet

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  • University of North Carolina at Chapel Hill

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