Cell Regulation By a Novel Estrogen Regulated Gene.
Abstract
This report describes the work conducted in the second year of a two year IDEA for which a no cost extension has been approved. Our original proposal was funded to study a human estrogen regulated transcript, HEM45. Recent homology studies indicate that HEM45 is reated to a family of proteins that have an exonuclease domain. These include DNA proof-reading proteins and proteins associated with mitotic structures. Studies in the reporting period have demonstrated altering patterns of HEM45 detectable in the cell cycle and an association with the mitotic spindle. These data strongly support a role for HEM45 in the cell cycle/proliferation. Ongoing studies address both the role and biochemical action of HEM4S.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADA358068
Entities
People
- Brian T. Pentecost