Importance of USF in Breast Cancer.
Abstract
USF is a family of transcription factors that can antagonize the activity of the Myc oncoproteins in cellular proliferation and transformation. The abundance and activity of the USF proteins in normal and tumorigenic breast epithelial cells were analyzed. All cell lines tested contained similar USF DNA-binding activity and similar expression levels of the ubiquitous USFl and USF2 polypeptides. In MCF-lOA, a normal breast epithelial cell line, the USF proteins acted as strong transcriptional activators at promoters containing USF-specific binding sites. In contrast, the transcriptional activity of USF was either decreased or absent in several breast cancer cell lines. This partial or complete loss of USF function is likely to contribute to the uncontrolled proliferation and tumorigenicity of breast cancer cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADA358199
Entities
People
- Micheele Sawadogo
Organizations
- University of Texas at Austin