A Cohort Study of the Relationship Between c-erbB-2 and Cyclin D1 Overexpression, p53 Mutation and/or Protein Accumulation, and Risk of Progression From Benign Breast Disease to Breast cancer; and Creation of a Bank of Benign Breast Tissue.

Abstract

We recently completed a case-control study nested within a cohort of 4,888 women with benign breast disease (BBD) who participated in the National Breast Screening Study (NBSS). This showed that accumulation of p53 protein was associated with an increased risk of progression to breast cancer (adjusted odds ratio (OR) 2.55; 95% confidence interval (Cl) 1.01-6.40), whereas c-erbB-2 protein overexpression was not (adjusted OR 0.65; 95% Cl 0.27-1.53).

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1998
Accession Number
ADA358205

Entities

People

  • Rita Kandel

Organizations

  • Mount Sinai Hospital, Toronto

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Biological Markers
  • Breast Cancer
  • Cancer
  • Carcinoma
  • Cell Line
  • Chemistry
  • Databases
  • Diseases And Disorders
  • Health Services
  • Medical Personnel
  • Neoplasms
  • Physicians
  • Polymerase Chain Reaction
  • Proteins
  • Public Health
  • Statistical Analysis

Fields of Study

  • Medicine

Readers

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