Role of Tissue Transglutaminases in Breast Cancer.
Abstract
Angiogenesis is vital to tumor growth and metastasis. The scope of this grant was to study in detail the role of Tissue transgiutaminase (tTG) during wound healing and tumorigenesis. In the first year of the grant proposal, we have described the expression, localization, molecular form and tTG's association with other major determinants of wound healing and tumorigenesis. Our findings clearly show that tTG is readily unregulated in wound healing and rat mammary adenocarcinoma and is associated with endothelial and inflammatory cells. Hypoxia, Vascular endothelial growth factor, Transforming growth factor heta and Tumor necrosisi factor alpha are also unregulated alongside tTG in those cells. tTG is quickly proteolysed in the tissues and that may have important consequences as tTG can hydrolyze ATP/GTP in its fragmented form. We are submitting these findings to Journal of Clinical investigation Proceedings of National Academy of Sciences and American Journal of Pathology where we have detailed the potential significance of these observations. We have also addressed most of the tasks detailed in the statement of work and are now set to proceed with the rest of the project.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1998
- Accession Number
- ADA358448
Entities
People
- Zishan A. Haroon
Organizations
- Duke University