The Role of HAP Kinases in Breast Cancer.

Abstract

Cells respond to extracellular stimuli through the recruitment of signal transduction pathways that in turn act to mount an appropriate response. Pathologic gain of function mutations in growth promoting signaling pathways have been implicated in the pathogenesis of breast cancer. Conversely, environmental stresses, including inflammatory cytokines and commonly used chemotherapeutic agents, activate signaling pathways that arrest cell growth; and can, in some instances, elicit programmed cell death (apoptosis). Exploitation of stress-regulated signaling pathways might therefore be a useful strategy in combating cancer. Alternatively, modulation of the necrotizing actions of cancer therapeutics could reduce the undesirable and disfiguring side effects of these treatments.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1998
Accession Number
ADA358856

Entities

People

  • John M. Kyriakis

Organizations

  • Massachusetts General Hospital

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Cytoskeleton
  • Fungi
  • Gene Expression
  • Health Services
  • Inhibition
  • Medical Personnel
  • Neoplasms
  • Peptide Growth Factors
  • Programmed Cell Death
  • Proteins
  • Tissues
  • Transcription Factors

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Economics
  • Immunology and Pathology