IGF Regulation of Cell Adhesion in Breast Cancer.
Abstract
A large number of recent studies have suggested that the insulin-like growth factor (IGF) system plays an important role in breast cancer progression. Mutational analyses of breast cancers have provided strong evidence to suggest that one component of the IGF system, the mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a tumor suppressor. At least three functions of M6P/IGF2R exist. These include the targeting for degradation of the mitogenic factor, insulin-like growth factor 2 (IGF2), the trafficking of mannose 6-phosphate proteins from the Golgi to lysosomes, and the activation of the negative growth regulator, transforming growth factor beta (TGFbeta). It has been hypothesized that loss or aberrant expression of M6P/IGF2R may result in increased tumor growth rates due to the disruption of negative growth regulatory mechanisms mediated by M6P/IGF2R. This proposal seeks to provide evidence that M6P/IGF2R is a negative growth regulator and further support the hypothesis that M6P/IGF2R is a tumor suppressor.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1998
- Accession Number
- ADA358873
Entities
People
- Stacey Da Costa
Organizations
- Georgetown University