Prediction & Assessment of Dermal Exposure
Abstract
The ultimate objective was to develop physicochemically and biologically relevant algorithms with which the rate and extent of absorption of a chemical following derma contact can be accurately predicted for diverse exposure scenarios. The rational for the proposed approach is based on the fact that manifestations of toxicity (local and/or systemic) following cutaneous exposure requires the transdermal penetration of the chemical. The unique permeation barrier properties of skin ensure that the kinetics of percutaneous absorption will determine the severity and time-course of any potential hazard. The long-term objective of meaningful risk assessment following dermal exposure, therefore, requires that the rate of skin penetration in man be predictable. The specific aims of the project were: (1) to derive, from a comprehensive database of the percutaneous absorption/penetration literature predictive ("structure-activity") algorithms to calculate a chemical's steady-state permeability (and constitutive diffusion and partition coefficients) across the skin. (2) To test the predictions of the unsteady-state modeling in vivo in humans using novel noninvasive methodology (accelerator mass spectrometry and attenuated total reflectance infrared spectroscopy).
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 31, 1998
- Accession Number
- ADA358903
Entities
People
- Annette L. Bunge
- Richard H. Guy
Organizations
- University of California, San Diego