Simulation of Protein Structure, Dynamics and Function in Organic Media.

Abstract

The overall goal of our ONR-sponsored research is to pursue realistic molecular modeling strudies pertinnent to the related properties of protein stability, dynamics, structure, function, and folding in aqueous solution. We have developed mixed solvent systems to investigate the conformational behavior of peptides and proteins in response to a change in environment. We have also been studying hydrophobic hydration and how it may affect the diffusivity of molecules and how it may be harnassed in the design of biomaterials.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1998
Accession Number
ADA359100

Entities

People

  • Valerie Daggett

Organizations

  • University of Washington

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Aqueous Solutions
  • Biomaterials
  • Biomedical Research
  • Chemical Synthesis
  • Chemistry
  • Computational Chemistry
  • Diffusion
  • Diffusion Coefficient
  • Dynamics
  • Hydrogen Bonds
  • Hydrophobic Properties
  • Molecular Dynamics
  • Proteins
  • Simulations
  • Solvents
  • Water

Fields of Study

  • Chemistry

Readers

  • Electrochemical Engineering/ Fuel Cell Technologies
  • Molecular Genetics
  • Ocean-Atmosphere Mesoscale Modeling, Data Assimilation, and Flux Boundary Layers