Her-2/Neu and Breast Cancer.

Abstract

The HER-2/neu proto-oncogene is developmentally expressed as a 185 kDa trans-membrane tyrosine Idnase. Overexpression of HER-2 occurs in up to 30% of human adenocarcinornas and has been most extensively studied in breast and ovarian cancers, where it predicts poor prognosis for survival of the patient. Although HER-2 gene amplification is a common mechanism for overexpression, many human tumors and cell lines display HER-2 mRNA and protein overexpression in excess of the level accountable by gene copy number, or in absence of gene amplification.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1998
Accession Number
ADA359622

Entities

People

  • Joni Doherty

Organizations

  • Oregon Health & Science University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biological Sciences
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Chemical Reactions
  • Chemistry
  • Genetic Code
  • Genetic Structures
  • Materials
  • Mrna
  • Neoplasms
  • Ovarian Cancer
  • Polymerase Chain Reaction
  • Rna Stability
  • Tissues

Fields of Study

  • Biology

Readers

  • Logistics and Supply Chain Management.
  • Molecular Biology and Genetics