The Effect of 2,3,4-Trimethylpentane on the Ultrastructure of Proximal Tubular Cells in Primary Cell Culture.

Abstract

To aid in the assessment of the risk of Air Force personnel working with hydrocarbon fuels and compounds, an attempt was made to further characterize the nephropathy that results from exposure to hydrocarbons. The purpose of this study was to isolate and establish purified primary cultures of male rat proximal tubular cells suitable for experimental exposure to sublethal concentrations of 2,3,4-trimethylpentane (TMP), a model hydrocarbon. Experiments were conducted to evaluated the cytotoxicity and metabolism of solubilized TMP in media containing or lacking the protein albumin.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1989
Accession Number
ADA359960

Entities

People

  • D.d. R. Mattie
  • J. J. Maslanka
  • M. R. Chase
  • N. J. Del Raso

Organizations

  • Armstrong Laboratory

Tags

Communities of Interest

  • Human Systems

DTIC Thesaurus Topics

  • Air Force
  • Air Force Personnel
  • Alkanes
  • Cells
  • Culture Techniques
  • Electron Microscopes
  • Electron Microscopy
  • Endoplasmic Reticulum
  • Hydrocarbon Fuels
  • Hydrocarbons
  • Medical Personnel
  • Metabolism
  • Microscopes
  • Microscopy
  • Transmission Electron Microscopy

Readers

  • Analytical Chemistry
  • Molecular and Cellular Biology
  • Toxicology/Environmental Toxicology