TGFa-myc Interactions in Mammary Tumorigenesis

Abstract

This grant continues to study the nature of the synergistic interaction of the growth factor TGFa and the nuclear protooncogene product c-myc for bitransgenic mouse mammary tumorigenesis. We found evidence of a multifactoral interaction of the two genes, involving cooperative stimulation of proliferation, anchorage independent colony formation, and suppression of cell death (apoptosis). In addition, we observed that the TGF alpha-related growth factor amphiregulin was likely to have tumor promoting effects similar to TGF alpha/myc interaction and the possible interaction of the two gene products in a novel paracrine mammary system in vivo.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1998
Accession Number
ADA360094

Entities

People

  • Robert B. Dickson

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Apoptosis
  • Biological Factors
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Genetics
  • Growth Factors
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Programmed Cell Death
  • Proteins
  • Salivary Glands

Readers

  • Molecular Biology and Genetics