The Effects of Cardiopulmonary Bypass on Hemostasis.
Abstract
The vast majority of cardiac surgical operations are performed with cardiopulmonary bypass. Blood contact with the extracorporeal circuit that is used during cardiopulmonary bypass elicits a wide spectrum of pathophysiological changes that affect a variety of organ systems. In a broad sense, the hematologic changes brought about by cardiopulmonary bypass are probably the most important of these pathophysiologic states because they result in the most pronounced clinical abnormality, increased postoperative bleeding, and because they impact on several of the abnormal clinical manifestations of other organ systems (e.g increased capillary permeability leading to respiratory abnormalities). It has long been recognized that cardiopulmonary bypass results in abnormal hemostasis that sometimes leads to excessive postoperative bleeding.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 12, 1993
- Accession Number
- ADA360144
Entities
People
- A. D. Michelson
- C. R. Valeri
- S. F. Khuri