Prevention of Postoperative Pericardial Adhesions with a Hyaluronic Acid Coating Solution: Experimental Safety and Efficacy Studies
Abstract
Postoperative pericardial adhesions complicate reoperative cardiac procedures. Topical applications of solutions containing hyaluronic acid (HA) have been shown to reduce adhesions following abdominal and orthopedic surgery. The mechanism by which HA solutions prevent adhesion formation is unknown, but may be due to a cryoprotective effect on mesothelial surfaces, thus limiting intraoperative injury. In this study we tested the efficacy and safety of HA coating solutions for the prevention of postoperative intrapericardial adhesion formation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 16, 1993
- Accession Number
- ADA360178
Entities
People
- G. T. Hodakowski
- J. D. Mitchell
- K. Neya
- R. Lee
- W. Harringer