Attenuation of IL-2 Induced Multi-System Organ Edema by Phalloidin and Antamanide.
Abstract
Interleukin (IL)-2 is a potent cytokine with diverse effects including the ability to stimulate lymphocyte differentiation into cells capable of lysing tumor. Its therapeutic efficacy is limited because of side effects characterized by breakdown of the microvascular barrier, edema and weight gain, the mechanisms of which are largely unknown. Control of the microvascular barrier, thought to be a major function of the endothelial cell (EC), is in part regulated by cytoskeletal contractile proteins associated with the plasma membrane. This study tests whether the cyclopeptide phalloidin, which maintains actin filament organization and distribution and reduces macromolecular flux across the EC junction in vitro, would similarly maintain barrier tightness and prevent early edema produced by IL-2 in vivo.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 25, 1990
- Accession Number
- ADA360181
Entities
People
- C. R. Valeri
- Gideon Goldman
- Herbert B. Hechtman
- Lester Kobzik
- Richard Welbourn
Organizations
- Boston University