Effects of Unmodified and Cross-Linked Stroma Free Hemoglobin Solutions on Blood Pressure and Renal Function in the Hypotensive Rat

Abstract

We have examined the short term systemic and rental effects of stroma free hemoglobin in anesthetized rats following hemorrhagic hypotension. Two forms of SFH, one unmodified and thd rental effects of stroma free hemoglobine other modified by intramolecular crosslinking (o-raffinose polyhemoglobin) were compared. Both the unmodified and modified forms of SFH increased MAP in the hypotensive rats from 61 +/- 6 to 111 +/- mm Hg and from 56 +/- 4 to 96 +/- 5 mm Hg respectively. Furthermore, the reduction in GFR associated with hemorrhage was reversed by both SFH solutions.

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Document Details

Document Type
Technical Report
Publication Date
Sep 09, 1993
Accession Number
ADA360205

Entities

People

  • Alex Thompson
  • Amy E. Mcgarry
  • C. R. Valeri
  • Wilfred Lieberthal

Organizations

  • Boston University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Blood Substitutes
  • Body Temperature
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cells
  • Excretion
  • Filtration
  • Hemorrhage
  • Inhibition
  • Measurement
  • Military Research
  • Molecules
  • Navy
  • United States

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology