The Effects of Temperature on Bleeding Time and Clotting Time in Normal Volunteers
Abstract
Bleeding time as a predictor of the potential for a bleeding disorder has been debated. The bleeding time measurement is known to be influenced by platelet count, mean platelet volume, platelet mass, von Willebrand's factor, factor VIII clotting protein, capillary integrity, vessel reactivity, and certain drugs, as well as by mechanical events associated with local perfusion pressure, resistance and blood flow. A bleeding time of less than 10 minutes has been arbitrarily established as a normal value. In this study , the effects of temperature on bleeding time and clotting time were evaluated in healthy volunteers. Previous studies in humans subjected to extracorporeal bypass surgery and in baboons revealed correlations among increased bleeding time, reduced local skin temperature, and a reduced thromboxane B2 level in shed blood collected at the template bleeding time site.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 12, 1991
- Accession Number
- ADA360221
Entities
People
- C. R. Valeri
- F. Pompeii
- G. Cassidy
- H. Macgregor
- R. Tinney
Organizations
- Boston University