MHC Genes and Breast Cancer.
Abstract
This study is based on preliminary results suggesting that the inheritance of the HLA (Human Leukocyte Antigen) class II DRBl* 0701 allele is linked to breast cancer in women under the age of 40. This data, if supported in a larger and more complete study (involving the genotyping of all HLA class II genes), would lend credence to the notion that immunogenetic factors contribute to the development of breast cancer. The goal of this study is to molecularly type all HLA class II genes in patients with breast cancer and in ethnically matched controls, in order to ascertain whether the inheritance of any of these genes contributes to susceptibility or resistance to breast cancer. Detailed molecular typing of DPB, DQB, and DRB1, 3, 4, and 5 alleles was performed on 144 controls. DNA was isolated from 70 freshly selected and cultured lymphoblastoid cell lines derived from patients with breast cancer. Molecular typing of DRB1, 3, 4, and 5 alleles was also performed on these patients. While preliminary results support earlier studies indicating a high frequency of DRB1*0701 in patients with breast cancer, clearly a larger analysis must be completed before attempting to statistically evaluate this information.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADA360222
Entities
People
- Shiv S. Pillai
Organizations
- Massachusetts General Hospital