Posttransfusion Survival and Distribution of 51-CR Labeled Fresh and Liquid Preserved Syngeneic Mouse Red Blood Cells

Abstract

Recent studies suggest that the transfusion of nonviable red blood cells (RBC) inhibits the reticuloendothelial system. The study reported here examines the in vivo distribution of nonviable RBC transfused in syngeneic mice. Within 1 hour after the transfusion of fresh 51-Cr-labeled RBC, blood samples, and liver, spleen, skeleton, lung, heart and kidneys were collected. The blood and organ samples and injectate were measured for radioactivity.

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Document Details

Document Type
Technical Report
Publication Date
Jun 03, 1991
Accession Number
ADA360261

Entities

People

  • C. R. Valeri
  • J. Dittmer
  • L. E. Pivacek
  • S. Prusty
  • T. Ichikura

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acid Citrate Dextrose
  • Anticoagulants
  • Arteries
  • Blood
  • Blood Cells
  • Blood Transfusions
  • Blood Volume
  • Body Weight
  • Bone Marrow
  • Cells
  • Gastrointestinal Tract
  • Reticuloendothelial System
  • Security
  • Sodium Compounds
  • Tissues
  • Veins
  • Vena Cava

Fields of Study

  • Biology

Readers

  • Immunology