Crystallization, X-Ray Structure Determination and Structure-Based Drug Design for Targeted Malarial Enzymes
Abstract
The goal of this project is to design selective anti-malarial compounds using a structure-based inhibitor design approach. Several potent inhibitors of Plasmodium falciparum lactate dehydrogenase have been identified. We are in the process of crystal structure analysis of the enzyme-inhibitor complexes. Attempts to determine the structure of the catalytic domain of Rab6 is in progress. Enzymatic characterization of monofunctional dihydropteroate synthetase will be done before crystallization effort is initiated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1998
- Accession Number
- ADA360337
Entities
People
- Lawrence J. Delucas
Organizations
- University of Alabama