Effect of Inherited Breast Cancer Susceptibility on Treatment Outcomes After Conservative Surgery and Radiation Therapy.
Abstract
The recent ability to test for an inherited susceptibility to breast cancer raises questions about the use of radiation therapy in patients with inherited mutations in BRCA1, BRCA2, or other breast cancer susceptibility genes. The presence of a mutation in a tumor suppressor gene, such as BRCA1, may have implications for patient management if patients with these mutations can be identified. Specifically, treatments such as breast conserving surgery and radiation therapy may be inappropriate if these patients are likely to be more susceptible to radiation-induced carcinogenesis or if they are more likely to recur locally in the breast because of multicentric disease. We have to date identified 90 eligible patients diagnosed with breast cancer at age 38 or younger and treated at the Joint Center for Radiation Therapy (JCRT) between 1987-95 of the 263 whom we expect to eventually contact. We have begun contacting these patients for a questionnnaire/blood draw session. Lymphocytes from these patients will be collected and immortalized. At the end of the two year collection period, testing for the presence of a germ-line BRCA1 mutation will be performed. Treatment outcome will then be compared between the groups of patients with and without mutations in BRCA1.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADA360396
Entities
People
- Asa J. Nixon
Organizations
- Dana–Farber Cancer Institute