Dual and Simultaneous Roles of Nucleophillic Delivery.

Abstract

We have elucidated the mechanisms of hydrolysis of phosphate diesters by acid and metal ion catalysis. In addition a new catalyst carrier (microgonotropens) to DNA and RNA have been invented, synthesized (patented) and the reactions with DNA studied. Such information is particularly important to those interested in the catalysis of hydrolysis of DNA and RNA.

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Document Details

Document Type
Technical Report
Publication Date
Feb 18, 1999
Accession Number
ADA360401

Entities

People

  • Thomas C. Bruice

Organizations

  • University of California, Santa Barbara

Tags

DTIC Thesaurus Topics

  • Acids
  • Catalysis
  • Catalysts
  • Chemical Reaction Properties
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Computational Chemistry
  • Deoxyribonucleic Acids
  • Esters
  • Hydrolysis
  • Metals
  • Nucleic Acids
  • Organic Chemistry
  • Peptides
  • Ribonucleic Acids

Fields of Study

  • Chemistry

Readers

  • Molecular Genetics
  • Organic Chemistry