Epithelin/Granulin Precursor Expression in Human Breast Carcinoma
Abstract
The purpose of the grant proposal DAMD 17-96-1-6072 was to design experiments in order to establish a solid foundation for the role of PCDGF in mammary epithelial cell biology and the involvement of its autocrine expression in the progression of the tumorigenicity in human breast carcinomas. Epithelin/granulin precursor is an 88 kDa glycoprotein originally purified as an autocrine growth factor from the highly tumorigenic mouse teratoma-derived cell line PC. For this reason this growth factor is also defined and known as PC cell derived growth factor (PCDGF). PCDGF belongs to a novel family of double cysteine rich polypeptides that include the 6 kDa epithelins and granulins originally purified from kidney extracts (epithelins) or granulocyte extracts (granulins). Experiments in the mouse cell lines indicated that PCDGF was overexpressed in the highly tumorigenic cells and that was positively correlated to the tumorigenic properties of the cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADA360413
Entities
People
- Ginette Serrero
Organizations
- University of Maryland, Baltimore