Estrogen Nuclear Receptor Coactivators in Pathogenesis of Breast Cancer

Abstract

This project focuses on the role of nuclear receptor coactivators in steroid dependent regulation of cell growth in pathogenesis of breast cancer. A novel nuclear receptor coactivator of transcription, p300 and CBP associated factor (p/CAF) has been shown to be required for estrogen, thyroid hormone, and retinoic acid-dependent gene expression. The histone acetyltransferase activity of p/CAF was demonstrated to play essential role in nuclear receptor dependent gene expression and it appeared to be transcription factor specific. The ligand-dependent association of p/CAF with nuclear receptor depends upon nuclear receptor corepressor (NCoR) dismissal. These data suggest that p/CAF complex plays a central role in nuclear receptor dependent gene regulation, a key element in steroid dependent cancer development.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1998
Accession Number
ADA360440

Entities

People

  • Edward Korzus

Organizations

  • University of California, San Diego

Tags

DTIC Thesaurus Topics

  • Acids
  • Amino Acids
  • Biomedical And Dental Materials
  • Breast Cancer
  • Cells
  • Chemistry
  • Gene Expression
  • Genetic Structures
  • Hormones
  • Neoplasms
  • Polymeric Films
  • Proteins
  • Retinoic Acids
  • Rodents
  • Thyroid Hormones
  • Transcription Factors
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics