Synthesis and Characterization of 5-Substituted-1,3-Diazacyclohecane Derivatives.
Abstract
Two synthetic routes to 5-substituted-1,3-diazacyclohexane derivatives 1 are reported. The first method involves treatment of l,3-diaminopropan-2-ol 2 with paraformaldehyde to yield 5-hydroxy-1,3-diazacyclohexane 3. A second method is based on the condensation of 2-bromo-2-nitro- 1,3 -propanediol with t-butylamine and formaldehyde to yield 1,3 -di(t-butyl)-5-bromo-5-nitro- 1,3 -diazacyclohexane 22. Functional group manipulations of 3 and 22 provide a number of novel 1,3-diazacyciohexanes functionalized at the 5-position. 5-Substitufed-lq 3-Diazacyclohexanes
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 15, 1998
- Accession Number
- ADA360626
Entities
People
- Jianguang Sun
- Kakal K. Dad
- Theodore Axenood
Organizations
- City College of New York