The Biological Effects of ADN on Hepatocytes: An EPR Study

Abstract

This project investigated the biological effects of ammonium dinitramide (ADN) on hepatocytes. It was hypothesized that ADN decomposes to form free radicals which would be deleterious to the body. The effects of ADN on the liver were studied because regardless of the route of exposure, once inside the body it will enter the bloodstream and ultimately pass through the liver. The leakage of the enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) was measured to ascertain the viability of WB 344 hepatocytes after a 24 h exposure to ADN. Electron paramagnetic resonance (EPR) spectroscopy was used to determine if ADN induced the production of free radicals.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1995
Accession Number
ADA360714

Entities

People

  • Alasdair J. Carmichael
  • Kenneth W. Dean
  • Linda Steel-goodwin
  • Sara E. Berty

Organizations

  • Armstrong Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Cells
  • Electron Paramagnetic Resonance
  • Electrons
  • Energetic Materials
  • Environmental Health
  • Epithelial Cells
  • Free Radicals
  • Frequency
  • Fuels
  • Governments
  • Paramagnetic Resonance
  • Resonance
  • Solid Fuels
  • Solid Rocket Oxidizers
  • Spectroscopy
  • Viability

Readers

  • Combustion science or combustion engineering.
  • Materials Science and Engineering.
  • Toxicology/Environmental Toxicology

Technology Areas

  • Microelectronics