Cardiovascular Response in Male Sprague-Dawley Rats Measured by Radiotelemetric Implants and Tailcuff Sphygmomanometry

Abstract

Tailcuff sphygmomanometry (Tailcuff) was compared to radiotelemetric implants (Implants) for monitoring blood pressure and heart rate in male Sprague-Dawley rats. Tailcuff has the intrinsic advantage of being noninvasive. However, Tailcuff requires at least several days (or more) of animal training to eliminate pulse artifacts generated by stress or gross body movements from close containment within unfamiliar surroundings. There is no training involved with implantation. Although several days are needed to insure recovery of the animal from surgery, no long-term, overt physiological stress was detected in animals subjected to implantation in terms of weight gain, liver to whole body ratios, gross changes in liver histology, or changes in blood pressure or heart rate (as measured by Tailcuff).

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1995
Accession Number
ADA360717

Entities

People

  • Carlyle D. Flemming
  • Frank W. Abernathy
  • William B. Sonntag

Tags

DTIC Thesaurus Topics

  • Air Force
  • Animal Training
  • Arteries
  • Body Weight
  • Cardiovascular Physiological Phenomena
  • Computers
  • Data Acquisition
  • Data Analysis
  • Data Science
  • Health Services
  • Heart Rate
  • Measurement
  • Pressure Measurement
  • Rodents
  • Stress (Physiology)
  • Surgery
  • Training

Fields of Study

  • Medicine

Readers

  • Acoustics.
  • Systems Analysis and Design
  • Toxicology/Environmental Toxicology