Quantitation of TCE-Induced Radicals in Liver of B6C3Fl Mice In Vivo: An EPR Study

Abstract

The total radicals generated in liver of B6C3Fl mice in vivo following exposure five days per week for 60 days to water, corn oil, or corn oil supplemented with trichloroethylene (TCE) was determined by EPR/spin trapping techniques. The concentration of the TCE added to the corn oil was 400, 800 or 1200 mg/kg body weight. Mice were gavaged with test material every day at 0900 and on the day of harvest at 1300 the mice were injected with spin trap 50 mg N-tert-butyl-a-nitrone/kg BW thirty minutes before euthanization by CO2 inhalation.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1996
Accession Number
ADA360800

Entities

People

  • Joanne Drerup
  • Linda Steel-goodwin
  • Sara Berty
  • William Hurtle
  • William J. Schmidt

Tags

DTIC Thesaurus Topics

  • Acids
  • Air Force
  • Analysis Of Variance
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Free Radicals
  • Lipids
  • Materials
  • Medical Personnel
  • Oxidative Stress
  • Peptide Growth Factors
  • Plant Oils
  • Standards
  • Statistical Analysis
  • Vitamin C

Fields of Study

  • Agricultural and Food sciences

Readers

  • Materials Science and Engineering.
  • Toxicology/Environmental Toxicology