Detection and Characterization of Autoantigens in Breast Cancer.

Abstract

By screening cDNA expression libraries with autologous breast cancer patient serum, we have identified and characterized two new gene products (Ngp-2 and LMO4), both of which appear to play vital roles in cellular growth and differentiation. The first autoantigen isolate Ngp 1 is a nucleolar GTP-binding protein which appears to be a vital component of the pre-mRNA processing machinery. LMO4 is partially homologous to a known oncogene, LMOl, and interacts with other gene products involved in gene regulation and signal transduction. Our observation that the expression of LMO4 transcripts in breast tumors differs from that in other tissues, and that rtMO4 interacts with a protein involved in estrogen receptor signal transduction, hint at a possible role of LMO4 in breast cancer, and merits further investigation. Furthermore, structural features of the LMO4 cDNA sequence all predict that this gene plays a vital role in the life of the organism.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1998
Accession Number
ADA360835

Entities

People

  • Janis Racevskis

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Antigens
  • Biomedical Research
  • Breast Cancer
  • Carrier Proteins
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Databases
  • Diseases And Disorders
  • Gene Expression
  • Genetic Code
  • Genetic Structures
  • Medical Personnel
  • Neoplasms
  • Proteins
  • Sequences

Fields of Study

  • Biology

Readers

  • Aerospace Propulsion Engineering.
  • Breast cancer cell signaling and growth regulation.
  • Molecular Genetics