The Interaction of Steroid Hormones and Oncogene in Breast Cancer.

Abstract

Breast cancer continues to be a prevailing disease among women in the United States. Though numerous models for breast cancer have been developed, the etiology of the disease remains obscure. Transgenic mice technology has been successfully used to target oncogenes to the mammary glands so that the role of these oncogenes in the development of breast cancer can be better understood. However, the constitutive expression of the oncogene does not allow for the assessment of critical time points at which the mammary glands are most susceptible to oncogenesis. Thus, it is most imperative that an inducible system be established to turn genes on and off, rendering it feasible to define the role of a candidate oncogene in mammary gland oncogenesis.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1998
Accession Number
ADA361178

Entities

People

  • Sophia Y. Tsai

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Animal Structures
  • Blood Vessels
  • Breast Cancer
  • Cells
  • Chemistry
  • Chromosomes
  • Diseases And Disorders
  • Epithelial Cells
  • Gene Expression
  • Genitalia
  • Glands
  • Hormones
  • Mammary Glands
  • Medical Personnel
  • Neoplasms
  • Pcr Testing
  • Tissues

Readers

  • Oncology (Cancer Research).
  • Theoretical Analysis.