Regulation of Epidermal Growth Factor Receptor Expression by PML in Human Breast Cancer

Abstract

The effects of retinoic acid (RA) in breast cancer have been widely studied. Treatment with RA leads to either growth arrest or apoptosis in breast cancer cells. The cyclin-dependent kinase inhibitor p2l WAF1/CIP1 may be involved in terminal differentiation associated growth arrest. We showed in this study that PML/RAR alpha increased the transcription of p21WAF1//CIP1 gene and the activation was further induced by RA treatment. Deletion analysis revealed a region upstream of the p2lWAFJ/ClPl promoter that is required for transactivation by PML/RAR alpha. Transient transfection of PML/RAR alpha in cells increased the endogenous p2l WAF1/CIPl protein levels.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1998
Accession Number
ADA361616

Entities

People

  • Khew-voon Chin

Tags

DTIC Thesaurus Topics

  • Acids
  • Biomedical And Dental Materials
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Cultured Cells
  • Epithelial Cells
  • Genetics
  • Growth Factors
  • Medical Personnel
  • Neoplasms
  • Peptide Growth Factors
  • Proteins
  • Retinoic Acids

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular Biology and Genetics