Analysis of Phenotypic Variability in Neurofibromatosis, Type 1.

Abstract

The clinical manifestations of NF1 are extremely variable. The purpose of this project is to characterize the sources of phenotypic variability in NF1 by using a combination of clinical, statistical, epidemiological, and molecular genetic methods. Our studies to date have included analysis of possible associations among all clinical features by simple 2x2 X(exp 2) analysis and more detailed analysis of selected features for the effects of covariates using stratification and log-linear methods. We found that age does not have a uniform effect on each variable and have developed a strategy using various approaches including linear regression to deal with this problem in future analyses. We have developed a list of possible clinical subtypes of NF1.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1998
Accession Number
ADA361846

Entities

People

  • Jan M. Friedman

Organizations

  • University of British Columbia

Tags

DTIC Thesaurus Topics

  • Arteries
  • Cancer
  • Congenital Abnormalities
  • Diseases And Disorders
  • Genetics
  • Health Services
  • Identification
  • Medical Personnel
  • Neoplasms
  • Nervous System
  • Neuromuscular Diseases
  • Peripheral Nervous System
  • Skin Diseases

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Molecular and Cellular Biology
  • Regression Analysis.

Technology Areas

  • Biotechnology