TCE Flagship Technical Paper: Data for Validaton of Human PBPK Model.
Abstract
The Armstrong Laboratory Occupational and Environmental Health Directorate, Toxicology Division is supporting the current flagship review of the environmental risks of trichloroethylene (TCE) being conducted by the U.S. Environmental Protection Agency (EPA) Operational Technologies assisted with the following objectives: 1) gathering physiologically-based pharmacokinetic (PBPK) data from published human studies which used TCE or its known metabolites as the dosing agent, 2) compiling physiological parameters (i.e., organ weight, blood volume, percent body fat and body weight) used in PBPK models, 3) calculating time weighted averages (TWAs) of 17 volunteer subjects exposed to TCE at Research Triangle Park (RTP) and 4) summarizing available human and animal toxicological studies on dichloroacetic acid (DCA). The main purpose of these tasks was to assist in refining TCE PBPK modeling efforts performed at the Toxicology Division by providing human data which may be used for statistical analysis and/or verification of PBPK modeling work.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1997
- Accession Number
- ADA362238
Entities
People
- Elaine A. Merrill
- Lisa A. May
- Teresa R Sterner