Concussive Effects of Low Frequency Sound Exposure

Abstract

We evaluated the threshold for concussive effects of low frequency underwater sound (LFS) exposure. In study 1, anesthetized (sodium pentobarbital 25mg/kg) male Sprague Dawley rats (n=96) were cannulated, ventilated (1.5% isoflurane), submerged, and exposed to 5 min. of LFS using a G40 calibrator. No alteration in cardiovascular function (arterial blood pH, p02, PC02, HR, or MABP) was observed during submersion. In study 2, animals were evaluated for two weeks following LFS exposure (150 Hz 180 dB, n=12; 250 Hz 194 dB, n=12), submersion only (n=11), or no submersion (n=11) using a battery of neurological motor tests. Cognitive function was assessed at one week using the Morris water maze (MWM). All animals were sacrificed at 15 days following for histological analysis. No effects of LFS on cardiovascular or neurological motor function were observed.

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Document Details

Document Type
Technical Report
Publication Date
Mar 31, 1999
Accession Number
ADA362965

Entities

People

  • Andrew B. Russ
  • Andrew N. Ritting
  • Kathryn E. Saatman
  • Shigeru Hoshino
  • Tracy K. Mcintosh

Organizations

  • Hospital of the University of Pennsylvania

Tags

DTIC Thesaurus Topics

  • Animal Structures
  • Arteries
  • Blood
  • Brain
  • Brain Injuries
  • Cardiovascular Physiological Phenomena
  • Cell Count
  • Cerebrovascular Disorders
  • Frequency
  • Heart Rate
  • Learning
  • Measurement
  • Motors
  • Physiological Effects
  • Platforms
  • Sound Pressure
  • Underwater Sound

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Toxicology/Environmental Toxicology