MUCI Facilitation of Growth in Chemically Induced Mammary Gland Tumors in Muc-1 Mutant and MUCI Transgenic Mice.
Abstract
In order to study the effect of the mucin Muc1 on tumor growth in the mammary glands of mice, a chemical carcinogenic combination of medroxyprogesteone acetate (MPA) and nitroso-methylurea was administered to wildtype C57BL/6 mice and mutant knock-out C57BL/6 mice unable to express Mucl. One week after implantation of time release MPA pellets, mice were injected with NMU. Mice received monthly injections of NMU for three months. Treatment failed to induce more than one tumor. Mice experienced excessive morbidity as a result of the chemical treatment. The trial was aborted after six months. Chemical carcinogenesis using MPA/NMU was not an efficient means to induce tumors in C57BL/6 mice for the study of Muc1 effect on growth immune response, or cell-matrix interactions in mice.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1998
- Accession Number
- ADA363618
Entities
People
- Russell J. Vanderboom