The Molecular Biology of the Sea Urchin Skeletal Matrix.
Abstract
A genomics approach yielded a new skeletogenic gene of the sea urchin embryo. This gene, SM37, is expressed coordinately with a gene encoding a known skeletogenic protein (SM50 gene) isolated earlier in our laboratory. Like SM50, SM37 is expressed only in skeletogenic cells. It encodes a protein that includes many copies of a glycine-rich repeat motif, similar in organization but different in sequence from that encoded by the SM50 gene. SM37 and SM50 are linked in the genome at a distance of about 12 kb, and each gene processes its own cis-regulatory system. These systems include the same sequence elements, and apparently function the same way during skeletogenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 26, 1999
- Accession Number
- ADA363771
Entities
People
- Eric H. Davidson
Organizations
- California Institute of Technology