Halofantrine Safety, Tolerance and Metabolism Studies.

Abstract

Halofantrine HCl is an antimalarial drug approved by the FDA for the treatment of mild to moderate malaria caused by Plasm odium falciparum or Plasm odium vivax(1). The present study was designed to investigate the safety, tolerance and pharmacokinetics of halofantrine HCl given in multiple doses in a Phase I study as part of the overall development of halofantrine as a prophylactic antimalarial drug.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1997
Accession Number
ADA364323

Entities

People

  • Ajaz Hussain
  • Darrell R. Abernethy
  • David Flockhart
  • David L. Wesche
  • Jean Barbey

Organizations

  • Food and Drug Administration

Tags

DTIC Thesaurus Topics

  • Antimalarials
  • Blood
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Heart Rate
  • Malaria
  • Materials
  • Metabolism
  • Pharmaceutical Preparations
  • Side Effects
  • Steady State
  • Therapy
  • Vital Signs

Fields of Study

  • Medicine

Readers

  • Parasitology and Pharmacology of Malaria.
  • Toxicology/Environmental Toxicology