Role of MYC in Anchorage-Dependent Growth
Abstract
When deprived of adhesion to a solid substrate, fibroblasts are unable to proliferate and arrest in the G1 phase of the cell cycle. We have shown that there is a similar adhesion -responsive (G1 restriction point in the immortalized human mammary epithelial cells line, 184A1N4. Unlike normal cells, transformed cells gain the ability to bypass this integrin-mediated control of proliferation and to grow in an anchorage-independent manner. We are examining the effect of c-Myc overexpression, which frequently occurs in breast cancer, in the adhesion-dependent regulation of the Gl-S phase transition.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADA364661
Entities
People
- Christelle M. Benaud
Organizations
- Georgetown University