Beta Catenin-Regulated Genes in Breast Cancer.
Abstract
Mutations of the APC tumor suppressor gene are linked to a number of hyperplastic events in humans and in mice, including breast cancer. Recent evidence indicates that the APC gene product may play an active role in the wnt-1 signaling pathway as a regulator of cytoplasmic B-catenin, a known mediator of transcription. Cytoplasmic B-catenin signaling may contribute to the transformation of cancerous cells, mediating the acquisition of a more aggressive, invasive phenotype. This project proposes to identify genes which may be regulated by B-catenin by using a novel method called gene-trapping, as well as through investigation of several "best guess" genes, including Leukemia Inhibitory Factor (LIF). Characterization of these genes will potentially elucidate another portion of the wnt-1 signaling pathway, and give fresh insight into the exact nature of the cell cycle perturbations caused by B-catenin and other components of the pathway.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1998
- Accession Number
- ADA364695
Entities
People
- Caroyln Feltes
Organizations
- Georgetown University