Malarial Ecology, Transmission, Immunology, Parasitology and Prophylaxis in Kenya
Abstract
The primary purpose was to study various aspects of malaria risk assessment, prevention, and treatment. Scope of work included testing malaria vaccines and drugs, and basic work on immunology and mosquito transmission of malaria. Accomplishments included: (1) completed a field test of Pf66 vaccine that showed it to be insufficiently efficacious to warrant further study; (2) began field tests of the recombinant RTSS circumsporozoite vaccine, which had proved 70% efficacious in Phase I; (3) discovered that a subpopulation of trophozoites sequester in the placenta putting both the mother and fetus at increased risk; (4) identified an immune mechanism that appears to explain the unusually high rates of hemolytic anemia encountered in severe malaria in Kenyan children; (5) determined that nearly 40% of infected children did not respond to Fansidar; (6) showed that the primaquine analog Tafenaquine (WR238605) had great promise as a one dose per month prophylaxis; (7) discovered 65 years of admissions records at Kericho that showed no relation between global warming and recent increases in incidence; and (8) used global positioning systems to determine that during the annual dry season Anophele gambiae continues to breed in a few small widely separated springs.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1999
- Accession Number
- ADA365439
Entities
People
- Davy K. Koech
Organizations
- Kenya Medical Research Institute