Development of a New Mouse Model to Study the Interactions of Obesity on the Development of Breast Cancer.
Abstract
Breast cancer is the most frequently diagnosed cancer in women (1). One risk factor that has been proposed to play a role in the development of postmenopausal breast cancer is increased body weight and/or body mass index (BMI) (weight/height2). Several reviews of the literature have shown that both case-control and prospective studies support this conclusion (2,3). A recent study of Italian women concluded that overweight accounted for 10.2% of postmenopausal breast cancer cases (4). Other studies have implicated weight gain as a risk factor for breast cancer development (5-8). In spite of these reports, roles for body weight and weight gain in breast cancer development have not been supported by all studies. This may be partially explained by technical factors. For example, conflicting results from human studies might be due to inaccurate recalled body weight. Also, whether weights from before or after menopause are used appears to make a difference in the conclusions drawn (9). In addition to these problems, there are other confounding factors such as the influences of ethnic and social backgrounds, and the potential for interactions with other risk factors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADA365453
Entities
People
- Margot P. Cleary
Organizations
- University of Minnesota