Gallium-Containing Estrogens as Receptor-Based Breast Tumor Imaging Agents
Abstract
We have conceived of an approach to prepare novel compounds for the estrogen receptor that might be useful in the imaging and diagnosis of breast cancer, by the creation of steroidal-based imaging agents which take advantage of the desirable properties of gallium as a radioisotope. We have made good progress on the preparation of the carbon skeletons needed to assemble these compounds. Synthetic routes to those compounds functionalized in the steroid D-ring have been developed, as well as a carbocyclic analog of the compounds designed to mimic the benzestrol class of estrogens. Future efforts will be directed at completing the synthesis of the gallium containing compounds of the D-ring class, which appear to be the most promising, and preparation of these compounds in radioactive form.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1998
- Accession Number
- ADA365485
Entities
People
- Richard R. Cesati
Organizations
- University of Illinois Urbana–Champaign