Factors that Effect Signal Transduction by the Estrogen Receptor.
Abstract
The overall goal of our laboratory is to define the mechanism of signal transduction and transcriptional regulation by the estrogen receptor (ER), a transcription factor that plays a critical role in the development, progression and hormone responsiveness of breast cancer cells. Our approach combines genetic, molecular and biochemical strategies to identify and characterize molecules that affect the ER signaling pathway. We have identified the Hsp90- associated co-chaperone, p23, as a key regulator of ER action and have also determined that ER is regulated by phosphorylation via the cyclin A/Cdk2 complex. Understanding of the communication between ER and these regulator factors is fundamental to understanding the mechanism of ER-regulated gene expression and may reveal novel points of intervention to be exploited in the development of new therapies for ER-dependent malignancies, such as breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1999
- Accession Number
- ADA365545
Entities
People
- Michael J. Garabedian
Organizations
- NYU Langone Health