Disaster Relief and Emergency Medical Services Project: Clinical and Basic Science Projects.
Abstract
The DREAMS basic science program complements the digital EMS program and has identical goals: faster diagnosis and treatment. We are studying how the lungs and liver synthesize its P450 defenses against toxins, so that we can accelerate that response and prevent chemical and biological injury. To speed diagnosis, we are developing fluorescent and luminescent markers for pathogens, cell types and cell injuries. We are developing heat imaging techniques, to triage victims and to diagnose injuries, including deep areas of hemorrhage, necrosis or inflammation. We are applying new treatments for cardiac arrest and cardiac failure, to sustain patients until hospital arrival, including the use of a field-implantable cardiac assist pump, made biocompatible by genetically engineered cells. To limit reperfusion injury, we are testing inhibitors of inflammation, oxidation and apoptosis. To speed healing, we are targeting macrophages and studying angiogenic growth factors. Many of these applications are supported by our new techniques that facilitate gene therapy. This is a broad and integrated program with both near-term and long-term benefits and a high likelihood that the basic research will spin off applications not yet foreseeable.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1998
- Accession Number
- ADA365782
Entities
People
- Ward Casscells
Organizations
- University of Texas Health Science Center at Houston