Improvement of Cultured Keratinocyte Grafts for Burn Wounds.
Abstract
This study, "Improvement of Cultured Keratinocyte Grafts for Burn Wounds", was modified from the original proposal after notification of early termination of funding of the original three year proposal. This modified study has demonstrated that keratinocyte allografts have reduced histocompatability antigen expression when grafted to burn recipients, and that this is associated with a decrease in sensitization as measured by cytotoxic T lymphocytes (CTL's) The study also demonstrated that significant reduction of CD-4 and CD-8 lymphocyte sub-populations did not affect CTL response to allograft. Furthermore, although cytokine levels are affected by bum injury, there was no consistent cytokine cascade system that would permit modification to alter keratinocyte allograft recognition or graft survival. Early studies with keratinocyte allografts from transgenic mice deficient in histocompatability antigen did find that they had significantly reduced immunogenecity and this technology may produce a universal donor keratinocyte.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1997
- Accession Number
- ADA366680
Entities
People
- Anthony A. Meyer
Organizations
- University of North Carolina at Chapel Hill