Isolation of a Receptor for WNT/Wingless Growth Factors
Abstract
The work done in this grant aims at elucidating the function of the Wnt signaling molecules in cancer. Wnt proteins are secreted and play important growth controlling roles, in particular in the mammary gland. They can act as oncogenes in mouse mammary tumors. The work was specifically aimed at identifying a receptor for Wnt proteins. Using cell biological and biochemical approaches we succeeded in finding a receptor for wingless called frizzled. During the past year, we have further characterized this receptor, as well as other genes in Drosophila involved in wingless function. We have also isolated a novel gene in Drosophila that modifies wingless signaling. This gene is highly conserved and may be involved in Wnt regulation in vertebrates as well.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADA366728
Entities
People
- Roel Nusse
Organizations
- Stanford University