Expression and Function of Heat Shock Proteins in the Mammalian Gut During Experimentally Induced Hypoxia and Exogenous Stress.
Abstract
The research was focused on characterization of the role of heat shock proteins during exogenous stress using mouse as model. The results of experiments provided evidence that heat shock protein 25 (Hsp25) maybe a specific factor protecting neuromuscular system from stress and stimulating subsequent regeneration. Hsp25 was specifically expressed in lower cholinergic motorneurons in normal conditions and was rapidly induced after heat shock and hypoxia..Hsp25 was colocalized with p38 and AKT kinases in the same cells. Specific p38 kinase inhibitor blocked expression of Hsp25 during regeneration. p38/AKT/Hsp25 cascade of signaling is critical for cell recovery.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 05, 1999
- Accession Number
- ADA366773
Entities
People
- Alexander K. Murashov
Organizations
- Columbia University