Structural Basis of EGER for Drug Discovery
Abstract
Our research addresses the pathogenesis of breast cancer, through an examination of the structural basis of EGFR dimerization leading to abnormal rapid growth characteristic of cancer. This analysis will not only increase our understanding of the mechanism by which EGFR overexpression results in unregulated breast cell proliferation, but may also provide insights on the mechanism of action of other growth factor receptors. Knowledge of the atomic structure of the EGFR dimer interface will also permit the rationale design of small molecule EGFR oligomerization antagonists capable of arresting breast cancer growth.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADA366901
Entities
People
- Cara Marks
Organizations
- University of California, San Francisco