Breast Cancer Associated Estrogen Receptors: Catechol Estrogen Receptors in ER-Minus Mice
Abstract
Our research will lead to a better understanding of the developmental, physiological, and biochemical roles of endogenous and environmental estrogens in breast cancer causation, prognosis and treatment. We have found in ER-alpha minus mice a uterine lactoferrin mRNA response to the catechol estrogen, 4-hydroxyestradiol, but not to estradiol. We hynothesize that the putative 4-hydroxyestradiol receptor will elicit additional responses distinct from estradiol and the classic ER-alpha and ER-Beta proteins.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1998
- Accession Number
- ADA366916
Entities
People
- Dennis B. Lubahn
Organizations
- University of Missouri